We developed Ampli diagnostic blocks after realizing that most paper diagnostics, while simple, were still subject to a lot of black box engineering. This renders the technology difficult to fabricate in low resource areas (where they stand to benefit the most). So we thought of the way electronics democratized fabrication by adopting breadboards where components enjoy hand placed modularity. No machining, special instruments or even hand dexterity is required to create a paperfluidic circuit. Biochemistry doesn’t have a breadboard, so we made one. Our goal was to create a plug and play set of blocks that could form, stop and modify reactions in real time. In glassware or microfluidics, this is almost impossible to do (the stopping and changing your mind part). Modular paper allows us to do that.
In our paper published in Advanced Healthcare Materials, we demonstrate our system with useful diagnostics for human health ranging from elemental glucose assays and infection diagnostics, to multiplexed peptide reporter cancer test and viral immunoassays. It was important to us that this worked with real reaction and not colored dyes because that can be a valley of death in the development of these systems.
Since then, we’ve engaged scientists and clinicians around the world in deploying our technologies so they can be equipped to detect epidemics in real time, at the front lines and care, and provide everyday care to the most vulnerable patients. Join us in our efforts!
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